The Nigeria Infodemic Management Operational Guideline offers a strategic framework for addressing the spread of misinformation, disinformation, and information overload related to public health threats. Built on five pillars—Coordination, Identification, Simplification, Amplification, and Quantification—the guideline aims to institutionalize infodemic management as a core component of Nigeria’s public health emergency preparedness and response. Developed by the Nigeria Centre for Disease Control and Prevention with key support from Breakthrough ACTION-Nigeria, the document draws on local and international best practices. Breakthrough ACTION provided critical technical assistance in operationalizing social and community listening systems, co-facilitating capacity building efforts, and supporting the Nigeria Infodemic Management Team in developing actionable insight reports. This resource serves as an addendum to Nigeria’s Multi-Hazard Risk Communication Guideline and positions infodemic management as a central feature of the country’s One Health approach.