This guide equips schoolteachers in Ghana with accurate, age-appropriate information to prevent and manage rabies, a deadly yet preventable zoonotic disease. Developed by Breakthrough ACTION Ghana in collaboration with national health and education stakeholders, the resource targets schoolchildren—the group most vulnerable to dog bites—with key prevention and response messages. The guide includes practical tips for bite prevention, outlines symptoms of rabies in humans and animals, and emphasizes immediate actions to take after an exposure. Designed for integration into Ghana’s School Health Education Program, the guide supports behavior change through classroom activities like health talks, role plays, and school club initiatives. It aligns with the global goal to eliminate human deaths from dog-mediated rabies by 2030 and empowers children as change agents in their families and communities.