In a groundbreaking partnership, Breakthrough ACTION and the Food and Agriculture Organization of the United Nations (FAO) spearheaded a transformative initiative to strengthen Liberia’s One Health platform. Recognizing the critical need for improved risk communication and community engagement, stakeholders underwent comprehensive training sessions facilitated by a new technical working group. Through this collaborative effort, Liberia has seen a remarkable evolution in its public health landscape, marked by the development of the country’s inaugural One Health Message Guide for Priority Zoonotic Diseases, a testament to the newfound synergy among stakeholders. This success story describes how Breakthrough ACTION and FAO addressed critical gaps in risk communication and laid the groundwork for sustained resilience in the face of future challenges by fostering transparency, ownership, and multisectoral engagement.